BDBM325411 (R)-3-(4-(4-(1-((R)-pentan- 2-yl)-1H-pyrazol-4- yl)pyrazolo[1,5-a]pyrazin- 6-yl)-1H-pyrazol-1- yl)propane-1,2-diol::US10189845, Example 73::US10730880, Example 73::US11028093, Example 73

SMILES CCC[C@@H](C)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](O)CO)c1

InChI Key InChIKey=ZXDMGKQCHWPBBL-RHSMWYFYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 325411   

TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325411((R)-3-(4-(4-(1-((R)-pentan- 2-yl)-1H-pyrazol-4- yl...)
Affinity DataIC50:  55nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325411((R)-3-(4-(4-(1-((R)-pentan- 2-yl)-1H-pyrazol-4- yl...)
Affinity DataIC50:  5.50E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325411((R)-3-(4-(4-(1-((R)-pentan- 2-yl)-1H-pyrazol-4- yl...)
Affinity DataIC50:  550nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325411((R)-3-(4-(4-(1-((R)-pentan- 2-yl)-1H-pyrazol-4- yl...)
Affinity DataIC50:  5.50E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325411((R)-3-(4-(4-(1-((R)-pentan- 2-yl)-1H-pyrazol-4- yl...)
Affinity DataIC50:  55nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325411((R)-3-(4-(4-(1-((R)-pentan- 2-yl)-1H-pyrazol-4- yl...)
Affinity DataIC50:  5.50E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325411((R)-3-(4-(4-(1-((R)-pentan- 2-yl)-1H-pyrazol-4- yl...)
Affinity DataIC50:  55nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325411((R)-3-(4-(4-(1-((R)-pentan- 2-yl)-1H-pyrazol-4- yl...)
Affinity DataIC50:  5.50E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325411((R)-3-(4-(4-(1-((R)-pentan- 2-yl)-1H-pyrazol-4- yl...)
Affinity DataIC50:  55nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325411((R)-3-(4-(4-(1-((R)-pentan- 2-yl)-1H-pyrazol-4- yl...)
Affinity DataIC50:  5.50E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325411((R)-3-(4-(4-(1-((R)-pentan- 2-yl)-1H-pyrazol-4- yl...)
Affinity DataIC50:  55nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325411((R)-3-(4-(4-(1-((R)-pentan- 2-yl)-1H-pyrazol-4- yl...)
Affinity DataIC50:  5.50E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent