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BDBM327883 (6-(3- (benzyloxy)phenyl) pyridin-3-yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 22::US9663496, Compound 22

SMILES: Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2cccc(OCc3ccccc3)c2)cc1

InChI Key: InChIKey=QSFRHVLXMAFXQR-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 327883   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM327883
PNG
((6-(3- (benzyloxy)phenyl) pyridin-3-yl)(4-(4- flu...)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2cccc(OCc3ccccc3)c2)cc1
Show InChI InChI=1S/C30H28FN3O2/c31-27-12-9-23(10-13-27)21-33-15-17-34(18-16-33)30(35)26-11-14-29(32-20-26)25-7-4-8-28(19-25)36-22-24-5-2-1-3-6-24/h1-14,19-20H,15-18,21-22H2
PDB

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UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)


BindingDB Entry DOI: 10.7270/Q2RV0R22
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))
BDBM327883
PNG
((6-(3- (benzyloxy)phenyl) pyridin-3-yl)(4-(4- flu...)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2cccc(OCc3ccccc3)c2)cc1
Show InChI InChI=1S/C30H28FN3O2/c31-27-12-9-23(10-13-27)21-33-15-17-34(18-16-33)30(35)26-11-14-29(32-20-26)25-7-4-8-28(19-25)36-22-24-5-2-1-3-6-24/h1-14,19-20H,15-18,21-22H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair