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BDBM327895 (4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- phenoxyphenylamino) pyridin-3-yl)methanone::US10377742, Compound 34::US9663496, Compound 34

SMILES: Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3ccc(Oc4ccccc4)cc3)nc2)cc1

InChI Key: InChIKey=SCZKOAZZRCYNFT-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 327895   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM327895
PNG
((4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- phenoxy...)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3ccc(Oc4ccccc4)cc3)nc2)cc1
Show InChI InChI=1S/C29H27FN4O2/c30-24-9-6-22(7-10-24)21-33-16-18-34(19-17-33)29(35)23-8-15-28(31-20-23)32-25-11-13-27(14-12-25)36-26-4-2-1-3-5-26/h1-15,20H,16-19,21H2,(H,31,32)
PDB

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UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)


BindingDB Entry DOI: 10.7270/Q2RV0R22
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))
BDBM327895
PNG
((4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- phenoxy...)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3ccc(Oc4ccccc4)cc3)nc2)cc1
Show InChI InChI=1S/C29H27FN4O2/c30-24-9-6-22(7-10-24)21-33-16-18-34(19-17-33)29(35)23-8-15-28(31-20-23)32-25-11-13-27(14-12-25)36-26-4-2-1-3-5-26/h1-15,20H,16-19,21H2,(H,31,32)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair