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BDBM327897 (6-(4- (cyanobenzyl)piperidin- 4-ylamino)pyridin-3- yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 36::US9663496, Compound 36

SMILES: Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(NC3CCN(Cc4ccc(cc4)C#N)CC3)nc2)cc1

InChI Key: InChIKey=AUSCOAAXXZHOLH-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 327897   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5'-AMP-activated protein kinase catalytic subunit alpha-2


(Homo sapiens (Human))
BDBM327897
PNG
((6-(4- (cyanobenzyl)piperidin- 4-ylamino)pyridin-3...)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(NC3CCN(Cc4ccc(cc4)C#N)CC3)nc2)cc1
Show InChI InChI=1S/C30H33FN6O/c31-27-8-5-25(6-9-27)22-36-15-17-37(18-16-36)30(38)26-7-10-29(33-20-26)34-28-11-13-35(14-12-28)21-24-3-1-23(19-32)2-4-24/h1-10,20,28H,11-18,21-22H2,(H,33,34)
PDB

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UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 750n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US10377742 (2019)


BindingDB Entry DOI: 10.7270/Q2RV0R22
More data for this
Ligand-Target Pair
ampk


(Homo sapiens (Human))
BDBM327897
PNG
((6-(4- (cyanobenzyl)piperidin- 4-ylamino)pyridin-3...)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(NC3CCN(Cc4ccc(cc4)C#N)CC3)nc2)cc1
Show InChI InChI=1S/C30H33FN6O/c31-27-8-5-25(6-9-27)22-36-15-17-37(18-16-36)30(38)26-7-10-29(33-20-26)34-28-11-13-35(14-12-28)21-24-3-1-23(19-32)2-4-24/h1-10,20,28H,11-18,21-22H2,(H,33,34)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 750n/an/an/an/a



Rigel Pharmaceuticals, Inc

US Patent


Assay Description
Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...


US Patent US9663496 (2017)


BindingDB Entry DOI: 10.7270/Q26975P8
More data for this
Ligand-Target Pair