BDBM329538 2-((1S,2S)-2-((2-methyl- 5-(1H-pyrazolo[3,4- b]pyridin-5-yl)pyrimidin- 4- yloxy)methyl)cyclopropyl) quinoline (enantiomer A)::US9663513, 151::US9663513, 152

SMILES Cc1ncc(-c2cnc3[nH]ncc3c2)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 329538   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM329538(2-((1S,2S)-2-((2-methyl- 5-(1H-pyrazolo[3,4- b]pyr...)
Affinity DataKi:  0.0200nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM329538(2-((1S,2S)-2-((2-methyl- 5-(1H-pyrazolo[3,4- b]pyr...)
Affinity DataKi:  1.78nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent