BDBM333466 N-[4-(3-chloro-4- fluorophenylamino)-7-((7-methyl-7- azaspiro[3.5]nonan-2- yl)methoxy)quinazolin-6-yl]- acrylamide::US10507209, Compound 18::US9730934, Compound 18

SMILES CN1CCC2(CC(COc3cc4ncnc(Nc5ccc(F)c(Cl)c5)c4cc3NC(=O)C=C)C2)CC1

InChI Key InChIKey=KJBZQIKLKWQVLL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 333466   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM333466(N-[4-(3-chloro-4- fluorophenylamino)-7-((7-methyl-...)
Affinity DataIC50:  1nMAssay Description:Assay Procedures:The abbreviations used in the following assay have the following meanings:HEPES: hydroxyethyl piperazine ethanesulfonic acid;Brij-35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM333466(N-[4-(3-chloro-4- fluorophenylamino)-7-((7-methyl-...)
Affinity DataIC50:  6.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM333466(N-[4-(3-chloro-4- fluorophenylamino)-7-((7-methyl-...)
Affinity DataIC50:  1.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM333466(N-[4-(3-chloro-4- fluorophenylamino)-7-((7-methyl-...)
Affinity DataIC50:  1nMAssay Description:Samples:Controls: Gefitinib, erlotinib hydrochloride, purchased from Anqing worldchem Co., LTD.; lapatinib ditosylate, purchased from Taizhou Xingche...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM333466(N-[4-(3-chloro-4- fluorophenylamino)-7-((7-methyl-...)
Affinity DataIC50:  6.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM333466(N-[4-(3-chloro-4- fluorophenylamino)-7-((7-methyl-...)
Affinity DataIC50:  1.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent