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BDBM336693 US9745283, Example 122

SMILES: COc1cc2nccc(Oc3ccc(NC(=O)c4nn(C)c(=O)n(CC#N)c4=O)cc3F)c2cc1OC

InChI Key: InChIKey=WUERKMWYGWNNJC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336693   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM336693
PNG
(US9745283, Example 122)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4nn(C)c(=O)n(CC#N)c4=O)cc3F)c2cc1OC
Show InChI InChI=1S/C24H19FN6O6/c1-30-24(34)31(9-7-26)23(33)21(29-30)22(32)28-13-4-5-18(15(25)10-13)37-17-6-8-27-16-12-20(36-3)19(35-2)11-14(16)17/h4-6,8,10-12H,9H2,1-3H3,(H,28,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



IGNYTA, INC.

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...


US Patent US9745283 (2017)


BindingDB Entry DOI: 10.7270/Q21Z46JR
More data for this
Ligand-Target Pair