BDBM34110 glucopyranosylidene-spiro-isoxazoline, 4e

SMILES OC[C@H]1O[C@@]2(CC(=NO2)c2ccc3ccccc3c2)[C@H](O)[C@@H](O)[C@@H]1O

InChI Key InChIKey=YKACTKXMYNIMHP-UYTYNIKBSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 34110   

TargetGlycogen phosphorylase, muscle form(Oryctolagus cuniculus (rabbit))
Universite De Lyon

LigandPNGBDBM34110(glucopyranosylidene-spiro-isoxazoline, 4e)
Affinity DataKi:  630nM ΔG°:  -8.59kcal/molepH: 6.8 T: 2°CAssay Description:Phosphorylase activity was measured in the direction of glycogen synthesis by the release of orthophosphate from Glc-1-P. The enzyme was assayed in g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, muscle form(Oryctolagus cuniculus (rabbit))
Universite De Lyon

LigandPNGBDBM34110(glucopyranosylidene-spiro-isoxazoline, 4e)
Affinity DataIC50:  630nMAssay Description:Binding affinity to rabbit muscular GPb by NMR binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM34110(glucopyranosylidene-spiro-isoxazoline, 4e)
Affinity DataIC50:  1.42E+4nMAssay Description:Inhibition of glycogen phosphorylase in human hepatocytes assessed as glucagon stimulated glycogen content after 3 hrs by colorimetric GOD methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Rattus norvegicus)
Universit£

Curated by ChEMBL
LigandPNGBDBM34110(glucopyranosylidene-spiro-isoxazoline, 4e)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of glycogen phosphorylase in Wistar rat hepatocytes assessed as decrease in glucagon stimulated glucose release after 3 hrs by glucose oxi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM34110(glucopyranosylidene-spiro-isoxazoline, 4e)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of glycogen phosphorylase in human hepatocytes assessed as decrease in glucagon stimulated glucose release after 3 hrs by glucose oxidase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed