BDBM34145 pyrrolidinylindole, (R)-5b

SMILES [H][C@]1(Cc2c[nH]c3ccc(NS(=O)(=O)c4ccc(cc4)C(F)(F)F)cc23)CCCN1C

InChI Key InChIKey=YUOITHDJQWZYHP-QGZVFWFLSA-N

Data  3 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 34145   

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universitat De Barcelona

LigandPNGBDBM34145(pyrrolidinylindole, (R)-5b)
Affinity DataKi:  0.400nM ΔG°:  -13.3kcal/mole EC50:  4.5nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universitat De Barcelona

LigandPNGBDBM34145(pyrrolidinylindole, (R)-5b)
Affinity DataKi:  0.400nMAssay Description:Inhibition of [3H]LSD binding to human 5-hydroxytryptamine 6 receptor expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universitat De Barcelona

LigandPNGBDBM34145(pyrrolidinylindole, (R)-5b)
Affinity DataKi:  10nMAssay Description:Inhibition of [3H]LSD binding to human 5-hydroxytryptamine 6 receptor expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universitat De Barcelona

LigandPNGBDBM34145(pyrrolidinylindole, (R)-5b)
Affinity DataEC50:  4.5nMAssay Description:Effective agonist concentration in cAMP release assay in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universitat De Barcelona

LigandPNGBDBM34145(pyrrolidinylindole, (R)-5b)
Affinity DataIC50:  21.6nMAssay Description:Inhibition of 5-HT stimulated cAMP production in HeLa cells expressing human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed