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BDBM342786 5-{4-[2-(2-Oxo-oxazolidin-3-yl)-acetyl]-piperazin-1-ylmethyl}-thiophene-2-carboxylic acid 2-trifluoromethoxy-benzylamide::US9776991, Example 156

SMILES: FC(F)(F)Oc1ccccc1CNC(=O)c1ccc(CN2CCN(CC2)C(=O)CN2CCOC2=O)s1

InChI Key: InChIKey=PXTAEHYTJBRHES-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 342786   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
EBifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM342786
PNG
(5-{4-[2-(2-Oxo-oxazolidin-3-yl)-acetyl]-piperazin-...)
Show SMILES FC(F)(F)Oc1ccccc1CNC(=O)c1ccc(CN2CCN(CC2)C(=O)CN2CCOC2=O)s1
Show InChI InChI=1S/C23H25F3N4O5S/c24-23(25,26)35-18-4-2-1-3-16(18)13-27-21(32)19-6-5-17(36-19)14-28-7-9-29(10-8-28)20(31)15-30-11-12-34-22(30)33/h1-6H,7-15H2,(H,27,32)
PDB

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KEGG

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Compounds were tested in a biochemical screening assay using recombinant sEH purified from Sf9 insect cells and an artificial substrate, (3-phenyl-ox...


US Patent US9776991 (2017)


BindingDB Entry DOI: 10.7270/Q2V126ZH
More data for this
Ligand-Target Pair