BDBM3436 6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine::6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine::6-arylpyrido[2,3-d]pyrimidine deriv. 18::ACS Chem. Biol. Compound 1

SMILES Nc1ncc2cc(c(N)nc2n1)-c1c(Br)cccc1Br

InChI Key InChIKey=HGIPWJYTPOHUGK-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 3436   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3436(6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7...)
Affinity DataIC50: >5.00E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3436(6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7...)
Affinity DataIC50:  1.30E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiotin carboxylase(Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22...)
Achaogen

Curated by ChEMBL
LigandPNGBDBM3436(6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7...)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant N-terminal His-tagged Pseudomonas aeruginosa PAO1 biotin carboxylase expressed in Escherichia coli Rosetta(DE3) pLysS cells...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiotin carboxylase(Escherichia coli (strain K12))
Pfizer

LigandPNGBDBM3436(6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7...)
Affinity DataIC50: <1nMpH: 8.0 T: 2°CAssay Description:Assays were performed in 384-well clear bottom plates (Corning; catalog no. 3702), that contained inhibitor solvated in DMSO. To each well of the pla...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3436(6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7...)
Affinity DataIC50:  1.60E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed