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BDBM344193 N-[6-(4-acetylpiperazin-1-yl)-2-(2-methoxyethoxyl)pyridin-3-yl]-5-(2-hydroxyethyl)-4-oxo-4,5,6,7-tetrahydrofuro[3,2-c]pyridine-3-carboxamide::US9777020, Example 87

SMILES: COCCOc1nc(ccc1NC(=O)c1coc2CCN(CCO)C(=O)c12)N1CCN(CC1)C(C)=O

InChI Key: InChIKey=PQRUIHMBZDGZMI-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 344193   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM344193
PNG
(N-[6-(4-acetylpiperazin-1-yl)-2-(2-methoxyethoxyl)...)
Show SMILES COCCOc1nc(ccc1NC(=O)c1coc2CCN(CCO)C(=O)c12)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C24H31N5O7/c1-16(31)27-7-9-28(10-8-27)20-4-3-18(23(26-20)35-14-13-34-2)25-22(32)17-15-36-19-5-6-29(11-12-30)24(33)21(17)19/h3-4,15,30H,5-14H2,1-2H3,(H,25,32)
PDB
MMDB

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US Patent
n/an/a 224n/an/an/an/an/an/a



AbbVie Inc

US Patent




US Patent US9777020 (2017)


BindingDB Entry DOI: 10.7270/Q2T155R7
More data for this
Ligand-Target Pair