BDBM346354 US10202377, Compound 433

SMILES CCCC(=O)Nc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cc(F)cc(CNS(C)(=O)=O)c1

InChI Key InChIKey=IRPGZYWCWMICIE-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 346354   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Samumed

US Patent
LigandPNGBDBM346354(US10202377, Compound 433)
Affinity DataEC50:  9nMAssay Description:Compound Screening: Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:2, 11-point d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene Wnt-1(Homo sapiens (human))
Samumed

US Patent
LigandPNGBDBM346354(US10202377, Compound 433)
Affinity DataIC50:  28.5nMAssay Description:The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent