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BDBM347126 2-(4-(methyl(3-(4-methylpiperazin-1- yl)phenyl)amino)-3-(trifluoromethyl) phenoxy)pyrido[3,4-d]pyrimidin-4-ol::US10202381, Example 133::US10208039, Example 133

SMILES: CN(c1cccc(c1)N1CCN(C)CC1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1C(F)(F)F

InChI Key: InChIKey=YKRZXSSMPBSNJT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 347126   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347126
PNG
(2-(4-(methyl(3-(4-methylpiperazin-1- yl)phenyl)ami...)
Show SMILES CN(c1cccc(c1)N1CCN(C)CC1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1C(F)(F)F
Show InChI InChI=1S/C26H25F3N6O2/c1-33-10-12-35(13-11-33)18-5-3-4-17(14-18)34(2)23-7-6-19(15-21(23)26(27,28)29)37-25-31-22-16-30-9-8-20(22)24(36)32-25/h3-9,14-16H,10-13H2,1-2H3,(H,31,32,36)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research Inc

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10208039 (2019)


BindingDB Entry DOI: 10.7270/Q241706J
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM347126
PNG
(2-(4-(methyl(3-(4-methylpiperazin-1- yl)phenyl)ami...)
Show SMILES CN(c1cccc(c1)N1CCN(C)CC1)c1ccc(Oc2nc(O)c3ccncc3n2)cc1C(F)(F)F
Show InChI InChI=1S/C26H25F3N6O2/c1-33-10-12-35(13-11-33)18-5-3-4-17(14-18)34(2)23-7-6-19(15-21(23)26(27,28)29)37-25-31-22-16-30-9-8-20(22)24(36)32-25/h3-9,14-16H,10-13H2,1-2H3,(H,31,32,36)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research Inc

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...


US Patent US10202381 (2019)


BindingDB Entry DOI: 10.7270/Q2SX6GBM
More data for this
Ligand-Target Pair