BDBM348 (2R,3R,4R,5R)-2,5-bis(benzyloxy)-3,4-dihydroxy-N,N'-bis[(1S)-2-methyl-1-(methylcarbamoyl)propyl]hexanediamide::1-Valine Methylamide deriv. 1::C2-Symmetric Inhibitor 2::C2-symmetric compound 5::CHEMBL105459::Diol-Based HIV-1 protease inhibitor 2
SMILES CNC(=O)[C@@H](NC(=O)[C@H](OCc1ccccc1)[C@H](O)[C@@H](O)[C@@H](OCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)NC)C(C)C
InChI Key InChIKey=QHMBKCCJSCSGHG-BQXGFVACSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 348
Affinity DataKi: 0.400nM ΔG°: -13.0kcal/molepH: 5.0 T: 2°CAssay Description:Ki values were determined by using a fluorescent substrate (DABCYL-gamma-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS). All incubations were performed a...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
LinköPing University
Curated by ChEMBL
LinköPing University
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Inhibitory activity against purified HIV-1 protease expressed in E. coli in sensitive fluorometric assayMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
LinköPing University
Curated by ChEMBL
LinköPing University
Curated by ChEMBL
Affinity DataKi: 0.400nM Kd: 11nM Koff: 3.55E+5s-1Assay Description:Association rate constant for the interaction between inhibitor and HIV-1 proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University
Linkoping University
Affinity DataKi: 0.800nM ΔG°: -12.6kcal/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Linkoping University
Linkoping University
Affinity DataKi: 0.800nM ΔG°: -12.6kcal/molepH: 5.0 T: 2°CAssay Description:A fluorimetric assay was used to determine the effects of the inhibitors on HIV-1 protease. This assay used an internally quenched fluorescent peptid...More data for this Ligand-Target Pair
Affinity DataKi: 3.80E+3nM ΔG°: -7.31kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
LinköPing University
Curated by ChEMBL
LinköPing University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:inhibitory activity against purified HIV-1 protease in a standardized spectrophotometric assay expressed in E. coliMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
LinköPing University
Curated by ChEMBL
LinköPing University
Curated by ChEMBL
Affinity DataKon: 0.00367M-1s-1Assay Description:Association rate constant for the interaction between inhibitor and HIV-1 proteaseMore data for this Ligand-Target Pair