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BDBM348976 N-(5-(4-(4-(2- morpholinoethyl)piperidine-1- carbonyl)phenyl)- [l,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 94

SMILES: O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCC(CCN4CCOCC4)CC3)n2n1)C1CC1

InChI Key: InChIKey=SGQDZFHRKMZEIL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 348976   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
JAK1 (aa 850-1154)


(Homo sapiens (Human))
BDBM348976
PNG
(N-(5-(4-(4-(2- morpholinoethyl)piperidine-1- carbo...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCC(CCN4CCOCC4)CC3)n2n1)C1CC1
Show InChI InChI=1S/C28H34N6O3/c35-26(22-6-7-22)30-28-29-25-3-1-2-24(34(25)31-28)21-4-8-23(9-5-21)27(36)33-14-11-20(12-15-33)10-13-32-16-18-37-19-17-32/h1-5,8-9,20,22H,6-7,10-19H2,(H,30,31,35)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Galapagos NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair