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BDBM349029 N-(5-(4-(4- phenethylpiperidine-1- carbonyl(phenyl)- [1,2,4]triazolo[1,5-a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 147

SMILES: O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCC(CCc4ccccc4)CC3)n2n1)C1CC1

InChI Key: InChIKey=VNSCXUBNYAKWST-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 349029   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
JAK1 (aa 850-1154)


(Homo sapiens (Human))
BDBM349029
PNG
(N-(5-(4-(4- phenethylpiperidine-1- carbonyl(phenyl...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCC(CCc4ccccc4)CC3)n2n1)C1CC1
Show InChI InChI=1S/C30H31N5O2/c36-28(24-13-14-24)32-30-31-27-8-4-7-26(35(27)33-30)23-11-15-25(16-12-23)29(37)34-19-17-22(18-20-34)10-9-21-5-2-1-3-6-21/h1-8,11-12,15-16,22,24H,9-10,13-14,17-20H2,(H,32,33,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Galapagos NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair