BindingDB logo
myBDB logout

BDBM349041 N-(5-(4-((methyl(4-(pyridin-2- yl)benzyl)amino)methyl)phenyl)- [1,2,4]triazolo[1,5- a]pyridin-2- yl)cyclopropanecarboxamide::US10206907, Compound 159

SMILES: CN(Cc1ccc(cc1)-c1ccccn1)Cc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12

InChI Key: InChIKey=SKGHAOQCRIOFRI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 349041   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
JAK1 (aa 850-1154)


(Homo sapiens (Human))
BDBM349041
PNG
(N-(5-(4-((methyl(4-(pyridin-2- yl)benzyl)amino)met...)
Show SMILES CN(Cc1ccc(cc1)-c1ccccn1)Cc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C30H28N6O/c1-35(19-21-8-12-23(13-9-21)26-5-2-3-18-31-26)20-22-10-14-24(15-11-22)27-6-4-7-28-32-30(34-36(27)28)33-29(37)25-16-17-25/h2-15,18,25H,16-17,19-20H2,1H3,(H,33,34,37)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Galapagos NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair