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BDBM349695 2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1,5-dimethyl-1H-imidazo[4,5-b]pyridine-6-carboxylic acid::US10208019, Example 2A-12

SMILES: Cc1nc2nc(CN3CCC(CC3)c3cccc(OCc4ccc(Cl)cc4F)n3)n(C)c2cc1C(O)=O

InChI Key: InChIKey=KKKIDDPSAYSHAZ-UHFFFAOYSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 349695   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM349695
PNG
(2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...)
Show SMILES Cc1nc2nc(CN3CCC(CC3)c3cccc(OCc4ccc(Cl)cc4F)n3)n(C)c2cc1C(O)=O
Show InChI InChI=1S/C27H27ClFN5O3/c1-16-20(27(35)36)13-23-26(30-16)32-24(33(23)2)14-34-10-8-17(9-11-34)22-4-3-5-25(31-22)37-15-18-6-7-19(28)12-21(18)29/h3-7,12-13,17H,8-11,14-15H2,1-2H3,(H,35,36)
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US Patent
n/an/an/an/a 340n/an/an/an/a



Pfizer Inc

US Patent


Assay Description
GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...


US Patent US10208019 (2019)


BindingDB Entry DOI: 10.7270/Q2WH2S4X
More data for this
Ligand-Target Pair