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BDBM349728 1-methyl-2-{[4-(6-{[4-(trifluoromethyl)benzyl]oxy}pyridin-2-yl)piperidin-1-yl]methyl}-1H-benzimidazole-6-carboxylic acid::US10208019, Example 9A-13

SMILES: Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(cc3)C(F)(F)F)n2)nc2ccc(cc12)C(O)=O

InChI Key: InChIKey=QVXROQVKRRYRSX-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 349728   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM349728
PNG
(1-methyl-2-{[4-(6-{[4-(trifluoromethyl)benzyl]oxy}...)
Show SMILES Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(cc3)C(F)(F)F)n2)nc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C28H27F3N4O3/c1-34-24-15-20(27(36)37)7-10-23(24)32-25(34)16-35-13-11-19(12-14-35)22-3-2-4-26(33-22)38-17-18-5-8-21(9-6-18)28(29,30)31/h2-10,15,19H,11-14,16-17H2,1H3,(H,36,37)
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US Patent
n/an/an/an/a 170n/an/an/an/a



Pfizer Inc

US Patent


Assay Description
GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...


US Patent US10208019 (2019)


BindingDB Entry DOI: 10.7270/Q2WH2S4X
More data for this
Ligand-Target Pair