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BDBM349780 2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-(2-hydroxyethyl)-1H-benzimidazole-6-carboxylic acid::US10208019, Example 10A-50

SMILES: OCCn1c(CN2CCC(CC2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O

InChI Key: InChIKey=SOGFEOQOINQMQT-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 349780   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))
BDBM349780
PNG
(2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...)
Show SMILES OCCn1c(CN2CCC(CC2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C28H28ClFN4O4/c29-21-6-4-20(22(30)15-21)17-38-27-3-1-2-23(32-27)18-8-10-33(11-9-18)16-26-31-24-7-5-19(28(36)37)14-25(24)34(26)12-13-35/h1-7,14-15,18,35H,8-13,16-17H2,(H,36,37)
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US Patent
n/an/an/an/a 290n/an/an/an/a



Pfizer Inc

US Patent


Assay Description
GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...


US Patent US10208019 (2019)


BindingDB Entry DOI: 10.7270/Q2WH2S4X
More data for this
Ligand-Target Pair