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BDBM351460 N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({3- [4-(methyloxy)phenyl]isoxazol-5- yl}methyl)oxy]quinazolin-4-amine::US9796704, Entry 180

SMILES: COc1ccc(cc1)-c1cc(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)on1

InChI Key: InChIKey=NHCXXCMLZIJGKZ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 351460   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ephrin type-B receptor 4


(Homo sapiens (Human))
BDBM351460
PNG
(N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({3- [4-(m...)
Show SMILES COc1ccc(cc1)-c1cc(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)on1
Show InChI InChI=1S/C26H20Cl2N4O4/c1-33-17-6-3-15(4-7-17)22-10-18(36-32-22)13-35-25-12-23-19(11-24(25)34-2)26(30-14-29-23)31-16-5-8-20(27)21(28)9-16/h3-12,14H,13H2,1-2H3,(H,29,30,31)
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a 525n/an/an/an/an/an/a



SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)


BindingDB Entry DOI: 10.7270/Q28K7C6V
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM351460
PNG
(N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({3- [4-(m...)
Show SMILES COc1ccc(cc1)-c1cc(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)on1
Show InChI InChI=1S/C26H20Cl2N4O4/c1-33-17-6-3-15(4-7-17)22-10-18(36-32-22)13-35-25-12-23-19(11-24(25)34-2)26(30-14-29-23)31-16-5-8-20(27)21(28)9-16/h3-12,14H,13H2,1-2H3,(H,29,30,31)
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n/an/a<50n/an/an/an/an/an/a



SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)


BindingDB Entry DOI: 10.7270/Q28K7C6V
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM351460
PNG
(N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({3- [4-(m...)
Show SMILES COc1ccc(cc1)-c1cc(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)on1
Show InChI InChI=1S/C26H20Cl2N4O4/c1-33-17-6-3-15(4-7-17)22-10-18(36-32-22)13-35-25-12-23-19(11-24(25)34-2)26(30-14-29-23)31-16-5-8-20(27)21(28)9-16/h3-12,14H,13H2,1-2H3,(H,29,30,31)
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n/an/a 525n/an/an/an/an/an/a



SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)


BindingDB Entry DOI: 10.7270/Q28K7C6V
More data for this
Ligand-Target Pair
Ephrin type-A receptor 2


(Homo sapiens (Human))
BDBM351460
PNG
(N-(3,4-dichlorophenyl)-6-(methyloxy)-7-[({3- [4-(m...)
Show SMILES COc1ccc(cc1)-c1cc(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)on1
Show InChI InChI=1S/C26H20Cl2N4O4/c1-33-17-6-3-15(4-7-17)22-10-18(36-32-22)13-35-25-12-23-19(11-24(25)34-2)26(30-14-29-23)31-16-5-8-20(27)21(28)9-16/h3-12,14H,13H2,1-2H3,(H,29,30,31)
PDB
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PC sid
UniChem
US Patent
n/an/a 525n/an/an/an/an/an/a



SYMPHONY EVOLUTION, INC.

US Patent


Assay Description
In AlphaScreen, when the donor and acceptor beads are close in proximity, a series of photochemical events will give rise to a fluorescent signal upo...


US Patent US9796704 (2017)


BindingDB Entry DOI: 10.7270/Q28K7C6V
More data for this
Ligand-Target Pair