BDBM35346 (S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypiperidin-1-yl)-1-oxopropan-2-yl)-1H-indole-2-carboxamide::5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID [1-(4-FLUOROBENZYL)-2-(4-HYDROXYPIPERIDIN-1YL)-2-OXOETHYL]AMIDE::5-Chloro-1H-indole-2-carboxylic acid [(S)-1-(4-fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-amide::CHEMBL99889::CP-320626

SMILES OC1CCN(CC1)C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1

InChI Key InChIKey=YDCGVASFVACWKF-NRFANRHFSA-N

Data  6 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 35346   

TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

LigandPNGBDBM35346((S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypip...)
Affinity DataIC50:  920nMpH: 6.8 T: 2°CAssay Description:The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

LigandPNGBDBM35346((S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypip...)
Affinity DataIC50:  920nMpH: 6.8 T: 2°CAssay Description:The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol 14-alpha demethylase(Homo sapiens (Human))
Act

Curated by ChEMBL
LigandPNGBDBM35346((S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypip...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

LigandPNGBDBM35346((S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypip...)
Affinity DataIC50:  2.40E+3nMAssay Description:In vitro inhibition of pig liver Glycogen phosphorylase A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, muscle form(Homo sapiens (Human))
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM35346((S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypip...)
Affinity DataIC50:  500nMAssay Description:Inhibition of Rabbit muscle glycogen phosphorylase B.More data for this Ligand-Target Pair
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

LigandPNGBDBM35346((S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypip...)
Affinity DataIC50:  205nMAssay Description:In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed