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BDBM356055 N-(6-((2- hydroxyacetamido)methyl)-4- phenylpyridin-3-yl)-3-(1- methyl-1H-pyrazol-3-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 55

SMILES: Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cnc(CNC(=O)CO)cc1-c1ccccc1

InChI Key: InChIKey=IIVDCUPTRDMNJC-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356055   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM356055
PNG
(N-(6-((2- hydroxyacetamido)methyl)-4- phenylpyridi...)
Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cnc(CNC(=O)CO)cc1-c1ccccc1
Show InChI InChI=1S/C26H22F3N5O3/c1-34-10-9-22(33-34)20-11-17(7-8-21(20)26(27,28)29)25(37)32-23-14-30-18(13-31-24(36)15-35)12-19(23)16-5-3-2-4-6-16/h2-12,14,35H,13,15H2,1H3,(H,31,36)(H,32,37)
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MMDB

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US Patent
n/an/a 14n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...


US Patent US9815846 (2017)


BindingDB Entry DOI: 10.7270/Q20P129R
More data for this
Ligand-Target Pair