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BDBM356078 2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(6-((1- methylureido)methyl)-2- phenylpyridin-3-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 78

SMILES: CN(Cc1ccc(NC(=O)c2cc(-c3ccn(C)n3)c(cc2F)C(F)(F)F)c(n1)-c1ccccc1)C(N)=O

InChI Key: InChIKey=DQTVFEJWTCTUHL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356078   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM356078
PNG
(2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(6-((1- m...)
Show SMILES CN(Cc1ccc(NC(=O)c2cc(-c3ccn(C)n3)c(cc2F)C(F)(F)F)c(n1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C26H22F4N6O2/c1-35(25(31)38)14-16-8-9-22(23(32-16)15-6-4-3-5-7-15)33-24(37)18-12-17(21-10-11-36(2)34-21)19(13-20(18)27)26(28,29)30/h3-13H,14H2,1-2H3,(H2,31,38)(H,33,37)
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a 1.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...


US Patent US9815846 (2017)


BindingDB Entry DOI: 10.7270/Q20P129R
More data for this
Ligand-Target Pair