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BDBM356132 US9815846, Compound 132

SMILES: CC(=O)NCc1cccc(c1)-c1nc(C)ncc1NC(=O)c1cc(-c2ccn(C)n2)c(cc1F)C(F)(F)F

InChI Key: InChIKey=KFPGLFOXLHTKOR-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356132   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM356132
PNG
(US9815846, Compound 132)
Show SMILES CC(=O)NCc1cccc(c1)-c1nc(C)ncc1NC(=O)c1cc(-c2ccn(C)n2)c(cc1F)C(F)(F)F
Show InChI InChI=1S/C26H22F4N6O2/c1-14-31-13-23(24(33-14)17-6-4-5-16(9-17)12-32-15(2)37)34-25(38)19-10-18(22-7-8-36(3)35-22)20(11-21(19)27)26(28,29)30/h4-11,13H,12H2,1-3H3,(H,32,37)(H,34,38)
PDB
MMDB

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PC cid
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US Patent
n/an/a 16n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...


US Patent US9815846 (2017)


BindingDB Entry DOI: 10.7270/Q20P129R
More data for this
Ligand-Target Pair