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BDBM356133 N-(4-(3-acetamidophenyl)-2- methylpyrimidin-5-yl)-2-fluoro- 5-(1-methyl-1H-pyrazol-3-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 133

SMILES: CC(=O)Nc1cccc(c1)-c1nc(C)ncc1NC(=O)c1cc(-c2ccn(C)n2)c(cc1F)C(F)(F)F

InChI Key: InChIKey=ZZOPPYJIDGZDPH-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356133   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM356133
PNG
(N-(4-(3-acetamidophenyl)-2- methylpyrimidin-5-yl)-...)
Show SMILES CC(=O)Nc1cccc(c1)-c1nc(C)ncc1NC(=O)c1cc(-c2ccn(C)n2)c(cc1F)C(F)(F)F
Show InChI InChI=1S/C25H20F4N6O2/c1-13-30-12-22(23(31-13)15-5-4-6-16(9-15)32-14(2)36)33-24(37)18-10-17(21-7-8-35(3)34-21)19(11-20(18)26)25(27,28)29/h4-12H,1-3H3,(H,32,36)(H,33,37)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 4.60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...


US Patent US9815846 (2017)


BindingDB Entry DOI: 10.7270/Q20P129R
More data for this
Ligand-Target Pair