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BDBM356146 2-fluoro-N-(2-phenyl-5,6,7,8- tetrahydro-1,6-naphthyridin-3- yl)-5-(pyridin-2-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 146

SMILES: Fc1cc(c(cc1C(=O)Nc1cc2CNCCc2nc1-c1ccccc1)-c1ccccn1)C(F)(F)F

InChI Key: InChIKey=MZVNKKLFPVLAEH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356146   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM356146
PNG
(2-fluoro-N-(2-phenyl-5,6,7,8- tetrahydro-1,6-napht...)
Show SMILES Fc1cc(c(cc1C(=O)Nc1cc2CNCCc2nc1-c1ccccc1)-c1ccccn1)C(F)(F)F
Show InChI InChI=1S/C27H20F4N4O/c28-21-14-20(27(29,30)31)18(23-8-4-5-10-33-23)13-19(21)26(36)35-24-12-17-15-32-11-9-22(17)34-25(24)16-6-2-1-3-7-16/h1-8,10,12-14,32H,9,11,15H2,(H,35,36)
PDB
MMDB

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PC cid
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US Patent
n/an/a 13n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...


US Patent US9815846 (2017)


BindingDB Entry DOI: 10.7270/Q20P129R
More data for this
Ligand-Target Pair