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BDBM356153 2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(7-oxo-2- phenyl-5,6,7,8-tetrahydro-1,6- naphthyridin-3-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 153

SMILES: Cn1ccc(n1)-c1cc(C(=O)Nc2cc3CNC(=O)Cc3nc2-c2ccccc2)c(F)cc1C(F)(F)F

InChI Key: InChIKey=YMSDBGADFOUYMD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356153   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM356153
PNG
(2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(7-oxo-2-...)
Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc3CNC(=O)Cc3nc2-c2ccccc2)c(F)cc1C(F)(F)F
Show InChI InChI=1S/C26H19F4N5O2/c1-35-8-7-20(34-35)16-10-17(19(27)11-18(16)26(28,29)30)25(37)33-22-9-15-13-31-23(36)12-21(15)32-24(22)14-5-3-2-4-6-14/h2-11H,12-13H2,1H3,(H,31,36)(H,33,37)
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MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 6.80n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...


US Patent US9815846 (2017)


BindingDB Entry DOI: 10.7270/Q20P129R
More data for this
Ligand-Target Pair