BindingDB logo
myBDB logout

BDBM356158 N-(6-(2-hydroxyethyl)-2-phenyl- 5,6,7,8-tetrahydro-1,6- naphthyridin-3-yl)-3-(1-methyl- 1H-pyrazol-3-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 158

SMILES: Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc2CN(CCO)CCc2nc1-c1ccccc1

InChI Key: InChIKey=GUKOVXOTZCPYHY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356158   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM356158
PNG
(N-(6-(2-hydroxyethyl)-2-phenyl- 5,6,7,8-tetrahydro...)
Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc2CN(CCO)CCc2nc1-c1ccccc1
Show InChI InChI=1S/C28H26F3N5O2/c1-35-11-9-24(34-35)21-15-19(7-8-22(21)28(29,30)31)27(38)33-25-16-20-17-36(13-14-37)12-10-23(20)32-26(25)18-5-3-2-4-6-18/h2-9,11,15-16,37H,10,12-14,17H2,1H3,(H,33,38)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.5n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...


US Patent US9815846 (2017)


BindingDB Entry DOI: 10.7270/Q20P129R
More data for this
Ligand-Target Pair