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BDBM356204 2-fluoro-N-(5-(oxazol-5- ylmethyl)-2-phenylpyridin-3-yl)- 5-(pyrimidin-2-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 204

SMILES: Fc1cc(c(cc1C(=O)Nc1cc(Cc2cnco2)cnc1-c1ccccc1)-c1ncccn1)C(F)(F)F

InChI Key: InChIKey=BKQHUSHYJFQTCY-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356204   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM356204
PNG
(2-fluoro-N-(5-(oxazol-5- ylmethyl)-2-phenylpyridin...)
Show SMILES Fc1cc(c(cc1C(=O)Nc1cc(Cc2cnco2)cnc1-c1ccccc1)-c1ncccn1)C(F)(F)F
Show InChI InChI=1S/C27H17F4N5O2/c28-22-12-21(27(29,30)31)19(25-33-7-4-8-34-25)11-20(22)26(37)36-23-10-16(9-18-14-32-15-38-18)13-35-24(23)17-5-2-1-3-6-17/h1-8,10-15H,9H2,(H,36,37)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 8.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...


US Patent US9815846 (2017)


BindingDB Entry DOI: 10.7270/Q20P129R
More data for this
Ligand-Target Pair