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BDBM356512 Cyclopropylmethyl 3-{1-[3-({[(2,2,2-trifluoroethyl)amino]carbonyl}amino)phenyl]-1H-benzimidazol-5-yl}benzoate::US10213427, Example 1

SMILES: FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1cccc(c1)C(=O)NCC1CC1

InChI Key: InChIKey=BWYWDLYSUHPSIP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356512   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM356512
PNG
(Cyclopropylmethyl 3-{1-[3-({[(2,2,2-trifluoroethyl...)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-n1cnc2cc(ccc12)-c1cccc(c1)C(=O)NCC1CC1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)15-32-26(37)34-21-5-2-6-22(13-21)35-16-33-23-12-19(9-10-24(23)35)18-3-1-4-20(11-18)25(36)31-14-17-7-8-17/h1-6,9-13,16-17H,7-8,14-15H2,(H,31,36)(H2,32,34,37)
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MMDB

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US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of compounds of the invention was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to ...


US Patent US10213427 (2019)


BindingDB Entry DOI: 10.7270/Q2765HM1
More data for this
Ligand-Target Pair