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BDBM357508 US10214519, Example 264

SMILES: Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)N1CCOCC1)-c1ccn(c1)S(C)(=O)=O

InChI Key: InChIKey=ZZLWJYDAXIXILH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 357508   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM357508
PNG
(US10214519, Example 264)
Show SMILES Cc1nc2c(cc(cc2n1-c1ccnc2c(Cl)cccc12)N1CCOCC1)-c1ccn(c1)S(C)(=O)=O
Show InChI InChI=1S/C26H24ClN5O3S/c1-17-29-26-21(18-7-9-31(16-18)36(2,33)34)14-19(30-10-12-35-13-11-30)15-24(26)32(17)23-6-8-28-25-20(23)4-3-5-22(25)27/h3-9,14-16H,10-13H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 770n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US10214519 (2019)


BindingDB Entry DOI: 10.7270/Q2P84F5Q
More data for this
Ligand-Target Pair