BDBM357733 N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5′-methyl-3′-oxo-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-[2,7]naphthyridine]-6′-yl)methyl)acrylamide::US10214528, Example 37::US10738048, Example 37::US11014923, Example 37::US11667635, Example 37::US9890156, Example 37

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(CNC(=O)C=C)c(C)c3C3(CC3)C2=O)c1F

InChI Key InChIKey=ABTMNPRJEDCYSE-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 357733   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50:  20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50:  20nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50:  20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50:  20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50:  20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM357733(N-((2′-(2,6-difluoro-3,5-dimethoxyphenyl)-5&...)
Affinity DataIC50: >200nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent