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BDBM360557 N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2-methyl-2-((4- (trifluoromethyl)pyridin-2- yl)oxy)propanamide::US9828369, Example 114

SMILES: COc1cccc(c1)-c1ccc(CNC(=O)C(C)(C)Oc2cc(ccn2)C(F)(F)F)c2cnccc12

InChI Key: InChIKey=LDAABNLIVUJMOO-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 360557   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360557
PNG
(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-2...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)C(C)(C)Oc2cc(ccn2)C(F)(F)F)c2cnccc12
Show InChI InChI=1S/C27H24F3N3O3/c1-26(2,36-24-14-19(9-12-32-24)27(28,29)30)25(34)33-15-18-7-8-21(22-10-11-31-16-23(18)22)17-5-4-6-20(13-17)35-3/h4-14,16H,15H2,1-3H3,(H,33,34)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.11E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)


BindingDB Entry DOI: 10.7270/Q2DN47C7
More data for this
Ligand-Target Pair