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BDBM360607 US9828369, Example 165::tert-butyl 3-(8-((3-(2,3- dichlorophenyl)ureido)methyl)isoquinolin- 5-yl)-5,6-dihydropyridine-1(2H)-carboxylate

SMILES: CC(C)(C)OC(=O)N1CCC=C(C1)c1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2cnccc12

InChI Key: InChIKey=CAEVTOLZNIPEID-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 360607   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM360607
PNG
(US9828369, Example 165 | tert-butyl 3-(8-((3-(2,3-...)
Show SMILES CC(C)(C)OC(=O)N1CCC=C(C1)c1ccc(CNC(=O)Nc2cccc(Cl)c2Cl)c2cnccc12
Show InChI InChI=1S/C27H28Cl2N4O3/c1-27(2,3)36-26(35)33-13-5-6-18(16-33)19-10-9-17(21-15-30-12-11-20(19)21)14-31-25(34)32-23-8-4-7-22(28)24(23)29/h4,6-12,15H,5,13-14,16H2,1-3H3,(H2,31,32,34)
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KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.31E+3n/an/an/an/an/an/a



Merck Sharpe & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9828369 (2017)


BindingDB Entry DOI: 10.7270/Q2DN47C7
More data for this
Ligand-Target Pair