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BDBM361820 US10221177, Compound 187

SMILES: Cn1c2ncn(CC(=O)Nc3cccc(n3)-c3ccc(F)c(F)c3)c2c(=O)n(Cc2ccccn2)c1=O

InChI Key: InChIKey=DKUIXNVMCXZCKN-UHFFFAOYSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 361820   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM361820
PNG
(US10221177, Compound 187)
Show SMILES Cn1c2ncn(CC(=O)Nc3cccc(n3)-c3ccc(F)c(F)c3)c2c(=O)n(Cc2ccccn2)c1=O
Show InChI InChI=1S/C25H19F2N7O3/c1-32-23-22(24(36)34(25(32)37)12-16-5-2-3-10-28-16)33(14-29-23)13-21(35)31-20-7-4-6-19(30-20)15-8-9-17(26)18(27)11-15/h2-11,14H,12-13H2,1H3,(H,30,31,35)
PDB

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US Patent
n/an/a 74n/an/an/an/an/an/a



Hydra Biosciences Inc

US Patent


Assay Description
Compounds of Formula (I) inhibit the TRPA1 channel, as shown by measuring the in vitro inhibition of human TRPA1, provided in data tables shown in Ta...


US Patent US10221177 (2019)


BindingDB Entry DOI: 10.7270/Q2445PR8
More data for this
Ligand-Target Pair