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BDBM363738 US9845310, Example 676.0

SMILES: COc1cccc(n1)-c1nnc(NS(=O)(=O)CCc2ncc(F)cn2)n1-c1c(OC)cccc1OC

InChI Key: InChIKey=KNYJBFZWAHBSSP-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 363738   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apelin receptor (APJ)


(Homo sapiens (Human))
BDBM363738
PNG
(US9845310, Example 676.0)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)CCc2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C22H22FN7O5S/c1-33-16-7-5-8-17(34-2)20(16)30-21(15-6-4-9-19(26-15)35-3)27-28-22(30)29-36(31,32)11-10-18-24-12-14(23)13-25-18/h4-9,12-13H,10-11H2,1-3H3,(H,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6n/an/an/an/a



Amgen Inc

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...


US Patent US9845310 (2017)


BindingDB Entry DOI: 10.7270/Q28P62TV
More data for this
Ligand-Target Pair