BindingDB logo
myBDB logout

BDBM364424 US9862707, Example 1

SMILES: Fc1cc(c(cc1C(=O)Nc1n(nc2cccnc12)-c1ccccc1)-c1ncccn1)C(F)(F)F

InChI Key: InChIKey=UPLIMAQWVNORIC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 364424   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM364424
PNG
(US9862707, Example 1)
Show SMILES Fc1cc(c(cc1C(=O)Nc1n(nc2cccnc12)-c1ccccc1)-c1ncccn1)C(F)(F)F
Show InChI InChI=1S/C24H14F4N6O/c25-18-13-17(24(26,27)28)15(21-30-10-5-11-31-21)12-16(18)23(35)32-22-20-19(8-4-9-29-20)33-34(22)14-6-2-1-3-7-14/h1-13H,(H,32,35)
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.20n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...


US Patent US9862707 (2018)


BindingDB Entry DOI: 10.7270/Q2FB5576
More data for this
Ligand-Target Pair