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BDBM364513 2-phenyl-3-({[3-pyrimidin-2-yl-4- (trifluoromethyl)phenyl]carbonyl} amino)-2H-pyrazolo[4,3-b]pyridine- 6-carboxamide::US9862707, Example 88

SMILES: NC(=O)c1cnc2c(NC(=O)c3ccc(c(c3)-c3ncccn3)C(F)(F)F)n(nc2c1)-c1ccccc1

InChI Key: InChIKey=CSIQWYJANFGMGW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 364513   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM364513
PNG
(2-phenyl-3-({[3-pyrimidin-2-yl-4- (trifluoromethyl...)
Show SMILES NC(=O)c1cnc2c(NC(=O)c3ccc(c(c3)-c3ncccn3)C(F)(F)F)n(nc2c1)-c1ccccc1
Show InChI InChI=1S/C25H16F3N7O2/c26-25(27,28)18-8-7-14(11-17(18)22-30-9-4-10-31-22)24(37)33-23-20-19(12-15(13-32-20)21(29)36)34-35(23)16-5-2-1-3-6-16/h1-13H,(H2,29,36)(H,33,37)
PDB
MMDB

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US Patent
n/an/a 13n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...


US Patent US9862707 (2018)


BindingDB Entry DOI: 10.7270/Q2FB5576
More data for this
Ligand-Target Pair