BDBM36538 5-fluoro-2-phenoxylphenol::PT55::US10071965, Compound PT55
SMILES Oc1cc(F)ccc1Oc1ccccc1
InChI Key InChIKey=DEMPPYSGPXLMNG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 36538
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Research Foundation For The State University Of New York
US Patent
The Research Foundation For The State University Of New York
US Patent
Affinity DataKi: 1.10nM ΔG°: -12.2kcal/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
3D Structure (crystal)TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Research Foundation For The State University Of New York
US Patent
The Research Foundation For The State University Of New York
US Patent
Affinity DataKi: 1.42nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Research Foundation For The State University Of New York
US Patent
The Research Foundation For The State University Of New York
US Patent
Affinity DataKi: 92.6nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
Affinity DataKi: 289nM ΔG°: -8.91kcal/molepH: 8.0 T: 2°CAssay Description:Inhibition constant binding to E-NAD+More data for this Ligand-Target Pair