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BDBM365759 1-{2-[({2,6-dimethoxy-4-[(2- methyl-3-phenylphenyl) methoxy]phenyl}methyl)amino] ethyl}piperidin-2-one::US9872852, Example 11

SMILES: COc1cc(OCc2cccc(c2C)-c2ccccc2)cc(OC)c1CNCCN1CCCCC1=O

InChI Key: InChIKey=YZASPJDRTJDVGZ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 365759   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM365759
PNG
(1-{2-[({2,6-dimethoxy-4-[(2- methyl-3-phenylphenyl...)
Show SMILES COc1cc(OCc2cccc(c2C)-c2ccccc2)cc(OC)c1CNCCN1CCCCC1=O
Show InChI InChI=1S/C30H36N2O4/c1-22-24(12-9-13-26(22)23-10-5-4-6-11-23)21-36-25-18-28(34-2)27(29(19-25)35-3)20-31-15-17-32-16-8-7-14-30(32)33/h4-6,9-13,18-19,31H,7-8,14-17,20-21H2,1-3H3
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 555n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
All binding studies were performed in an HTRF assay buffer consisting of dPBS supplemented with 0.1% (withv) bovine serum albumin and 0.05% (v/v) Twe...


US Patent US9872852 (2018)


BindingDB Entry DOI: 10.7270/Q2RN3B42
More data for this
Ligand-Target Pair