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BDBM366960 1-[4-[2-[4-(3- aminoazetidine-1- carbonyl)anilino]- [1,2,4]triazolo[1,5- a]pyridin-8-yl]-3,6- dihydro-2H-pyridin-1- yl]-4,4,4-trifluoro- butan-1-one::US9873709, Example 2-256

SMILES: NC1CN(C1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC(F)(F)F)cc1

InChI Key: InChIKey=MBHIHIBQGVZCKH-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 366960   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM366960
PNG
(1-[4-[2-[4-(3- aminoazetidine-1- carbonyl)anilino]...)
Show SMILES NC1CN(C1)C(=O)c1ccc(Nc2nc3c(cccn3n2)C2=CCN(CC2)C(=O)CCC(F)(F)F)cc1
Show InChI InChI=1S/C25H26F3N7O2/c26-25(27,28)10-7-21(36)33-12-8-16(9-13-33)20-2-1-11-35-22(20)31-24(32-35)30-19-5-3-17(4-6-19)23(37)34-14-18(29)15-34/h1-6,8,11,18H,7,9-10,12-15,29H2,(H,30,32)
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US Patent
0.670n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...


US Patent US9873709 (2018)


BindingDB Entry DOI: 10.7270/Q2CC130F
More data for this
Ligand-Target Pair