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BDBM368323 US10227338, Example 110

SMILES: CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccccn1)C(F)(F)F

InChI Key: InChIKey=OUFFFAQTQYVWGY-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 368323   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM368323
PNG
(US10227338, Example 110)
Show SMILES CNCCN(C)c1cc(ccc1Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1ccccn1)C(F)(F)F
Show InChI InChI=1S/C22H22ClF4N5O2S/c1-28-9-10-32(2)19-11-14(22(25,26)27)6-7-17(19)30-18-13-16(24)20(12-15(18)23)35(33,34)31-21-5-3-4-8-29-21/h3-8,11-13,28,30H,9-10H2,1-2H3,(H,29,31)
PDB

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PC cid
PC sid
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US Patent
n/an/a 70n/an/an/an/an/an/a



Daewoong Pharmaceutical Co., Ltd.

US Patent


Assay Description
In order to measure the sodium ion channel blocking effect, an IonFlux16 Auto patch clamp system (Fluxion, Inc.) and a plate for exclusive use were u...


US Patent US10227338 (2019)


BindingDB Entry DOI: 10.7270/Q2F47RFM
More data for this
Ligand-Target Pair