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BDBM368987 N-[3-fluoro-4-[7-methoxy-6-(3- morpholinopropoxy)quinazolin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0251

SMILES: COc1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3F)c2cc1OCCCN1CCOCC1

InChI Key: InChIKey=ZACKEGOJGJLAKP-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368987   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM368987
PNG
(N-[3-fluoro-4-[7-methoxy-6-(3- morpholinopropoxy)q...)
Show SMILES COc1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3F)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C25H29FN4O5S/c1-33-23-15-22-20(14-24(23)35-10-2-7-30-8-11-34-12-9-30)25(28-16-27-22)19-6-3-17(13-21(19)26)29-36(31,32)18-4-5-18/h3,6,13-16,18,29H,2,4-5,7-12H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1FZW
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM368987
PNG
(N-[3-fluoro-4-[7-methoxy-6-(3- morpholinopropoxy)q...)
Show SMILES COc1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3F)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C25H29FN4O5S/c1-33-23-15-22-20(14-24(23)35-10-2-7-30-8-11-34-12-9-30)25(28-16-27-22)19-6-3-17(13-21(19)26)29-36(31,32)18-4-5-18/h3,6,13-16,18,29H,2,4-5,7-12H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
1.05E+5n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1FZW
More data for this
Ligand-Target Pair