BDBM370412 US10233189, Compound 3 of Comparative Examples::US10787457, Compound 3 of Comparative Ex.::US11014930, Compound 3 of Comparative Examples::US11236096, Compound 3 of Comparative Ex.

SMILES Cc1c[nH]c(NC(=O)c2nn(C3CCC3)c3ncnc(N)c23)n1

InChI Key InChIKey=ZESXKBIEAKGGSY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 370412   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370412(US10233189, Compound 3 of Comparative Examples | U...)
Affinity DataIC50:  486nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370412(US10233189, Compound 3 of Comparative Examples | U...)
Affinity DataIC50:  486nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370412(US10233189, Compound 3 of Comparative Examples | U...)
Affinity DataIC50:  486nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370412(US10233189, Compound 3 of Comparative Examples | U...)
Affinity DataIC50:  486nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent