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BDBM371057 US10239843, Example 164

SMILES: Cc1cc(COc2nc3ccc(cc3c(=O)n2Cc2cnc(C)s2)S(=O)(=O)NC2(C)CC2)n(C)n1

InChI Key: InChIKey=QROYTPZFYDKIQE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371057   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371057
PNG
(US10239843, Example 164)
Show SMILES Cc1cc(COc2nc3ccc(cc3c(=O)n2Cc2cnc(C)s2)S(=O)(=O)NC2(C)CC2)n(C)n1
Show InChI InChI=1S/C23H26N6O4S2/c1-14-9-16(28(4)26-14)13-33-22-25-20-6-5-18(35(31,32)27-23(3)7-8-23)10-19(20)21(30)29(22)12-17-11-24-15(2)34-17/h5-6,9-11,27H,7-8,12-13H2,1-4H3
PDB

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PC cid
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US Patent
n/an/a 343n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair