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BDBM371147 US10239843, Example 254

SMILES: Cn1cc(Cn2c(=O)n(CCNC(=O)OC(C)(C)C)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)cn1

InChI Key: InChIKey=HSKULTOYBGGXJS-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371147   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371147
PNG
(US10239843, Example 254)
Show SMILES Cn1cc(Cn2c(=O)n(CCNC(=O)OC(C)(C)C)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)cn1
Show InChI InChI=1S/C24H32N6O6S/c1-23(2,3)36-21(32)25-10-11-29-19-7-6-17(37(34,35)27-24(4)8-9-24)12-18(19)20(31)30(22(29)33)15-16-13-26-28(5)14-16/h6-7,12-14,27H,8-11,15H2,1-5H3,(H,25,32)
PDB

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antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 998n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair