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BDBM371226 US10239843, Example 333

SMILES: CN1CCC(CNC(=O)c2nn(Cc3cc(C)no3)c(=O)c3cc(ccc23)S(=O)(=O)NC2(C)CC2)CC1

InChI Key: InChIKey=HITLITNGINFNKT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371226   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371226
PNG
(US10239843, Example 333)
Show SMILES CN1CCC(CNC(=O)c2nn(Cc3cc(C)no3)c(=O)c3cc(ccc23)S(=O)(=O)NC2(C)CC2)CC1
Show InChI InChI=1S/C25H32N6O5S/c1-16-12-18(36-28-16)15-31-24(33)21-13-19(37(34,35)29-25(2)8-9-25)4-5-20(21)22(27-31)23(32)26-14-17-6-10-30(3)11-7-17/h4-5,12-13,17,29H,6-11,14-15H2,1-3H3,(H,26,32)
PDB

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antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 781n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair