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BDBM371265 US10239843, Example 372

SMILES: CN1CCC(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(C)CC2)CC1

InChI Key: InChIKey=KWCCHBFINWQIJB-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371265   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371265
PNG
(US10239843, Example 372)
Show SMILES CN1CCC(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(C)CC2)CC1
Show InChI InChI=1S/C24H32N6O4S/c1-24(8-9-24)26-35(33,34)19-4-5-21-20(12-19)22(31)30(16-18-13-25-28(3)14-18)23(32)29(21)15-17-6-10-27(2)11-7-17/h4-5,12-14,17,26H,6-11,15-16H2,1-3H3
PDB

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antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 146n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair